150 Club

Your Longevity Starts Here.

AI-Powered Genetic Intelligence Platform

PolyU Micro Fund 2025-26 Cohort 2 Confidential
Speaker
We are 150 Club. We're building the intelligence layer between your DNA test and your daily health decisions.

The Problem

The “So What?” Gap

Personal experience
“I spent $600 on a CircleDNA Whole Exome test. I got 84 pages of genetic data. I had no idea what to do with any of it.”
— Billy Lui, Co-Founder
Static Reports
84-page PDFs that sit unread. Zero behavior change.
Data Silos
DNA, blood, wearables — separate worlds, no connection.
One-Time & Dead
Reports never update when science reclassifies your variants.

The Opportunity

50M+
DNA tests taken globally
24% CAGR
~0%
behavior change from genetic risk data alone
Hollands et al., BMJ 2016
$5,000+
cost of functional medicine consultation
Only alternative

“50 million people have genetic data they can’t act on. The only alternative costs $5,000+. We close this gap at $25/month.”

Speaker
This problem is personal. I spent $600 on a CircleDNA test and got 84 pages I couldn’t act on. Over 50 million people have the same experience — and behavior change from the results is essentially zero, proven across 18 RCTs. The only alternative is $5,000+ functional medicine. We close this gap at $25 a month.

The Solution

Upload Once, Improve Forever

01

Upload

Drop your DNA report. Auto-extract every variant.

< 2 min
Upload Report
CircleDNA_Report.pdf
7.3 MB
Analyze My DNA
02

Analyze

AI cross-references ClinVar, PharmGKB & knowledge base.

< 3 min
Risk Overview
574 traits
Low 389
Mod 142
High 43
03

Protocol

Personalized supplements, nutrition & exercise plans.

< 10 min
Your Protocol
Essential Vitamin D3 4K IU
Essential Omega-3 2g
Recommend Methylfolate 800mcg
Mediterranean Diet
04

Track & Evolve

Add blood work. AI refines your protocol over time.

Ongoing
Biomarker Trends
Vitamin D (ng/mL)
JanMarJunSep
45
ng/mL
Updated D3: 4K→2K IU

Upload to protocol in under 10 minutes. Then your protocol keeps getting smarter — every blood test, every update, every new study.

Speaker
Four steps. Upload your DNA, AI analyzes against research databases, get a personalized protocol, then track your biomarkers and watch the AI refine your plan over time. It’s not a one-time report — it’s a living system.

The Vision

Your DNA Is Just the Start

Genetic data alone drives ~0% behavior change (Hollands, BMJ 2016). 150 Club wraps your DNA in a living system that turns static data into measurable health outcomes.

Genetic
Foundation
Insights
DNA + lab results decoded into plain-language findings
Protocols
Personalized supplements, nutrition & exercise plans
Action
Guided daily routines integrated into real life
Outcomes
Measurable biomarker improvements & health changes
AI generates plans
Guided routines
Health changes
New data refines AI
1

Compounding Intelligence

Every cycle generates new data. AI learns what works for YOUR genetics & phenotype.

2

Living, Not Static

Protocols evolve with new research, new blood work, and new outcomes. Never a dead PDF again.

3

Defensible Moat

Our moat isn’t the genetic test — it’s the compounding intelligence from thousands of genetic × biomarker × protocol interactions.

Every turn of the flywheel makes the AI smarter and protocols more precise. Static reports can’t do this.
Speaker
Genetic data alone has zero percent effectiveness at driving behavior change. But when you add real biomarker feedback, personalized protocols, guided action, and outcome tracking, you create a flywheel where every cycle makes the system smarter. Our moat isn’t the test — it’s the compounding intelligence.

Competitive Landscape

Where We Sit

Genetic Depth →
Independence →
SelfDecode
CircleDNA
Nucleus
Whoop
Bevel
150 Club
Genetic + Independent
No Genetics + Sells Products
All-in-One
DNA Test
Health SaaS
Three Types of Players
All-in-One — SelfDecode
Test + interpret + sell supplements. Recommendations biased toward their own products.
DNA Test — CircleDNA, Nucleus
Static report filed away. No living protocols, no tracking, no follow-up.
Health SaaS — Whoop, Bevel
Great tracking + blood labs. But generic — ignores your genetic blueprint.
Self
Decode
Circle
DNA
Whoop
150
Club
Genetic intelligence
Static
Living protocols
Coach
Biomarker tracking
Labs
Any DNA provider
N/A
Independent
Sells supps
Sells kits
Sells labs

Only 150 Club combines genetic intelligence + living protocols + biomarker tracking — with pure subscription, zero product sales.

Speaker
Three types of players. All-in-one platforms like SelfDecode sell supplements alongside interpretation — their recommendations follow the money. DNA test providers like CircleDNA give you a report and walk away. Health SaaS like Whoop has great tracking but ignores your genetics entirely. We’re the only platform that bridges all three — with zero product sales.

Market Opportunity

The Size of the Prize

TAM Consumer Genomics ($3B) + Nutrigenomics ($0.8B) + Longevity ($29B) $33B
SAM APAC DTC genetics — ~$500M in 2025, $1.5B+ by 2030 $1.5B
SOM HK + SG Year 1 (bottom-up) $27K ARR
Category Genetic Intelligence Platform We don’t test — we interpret
20%
APAC DTC Genetics CAGR
19%
Biohacking Market CAGR
$29B
Longevity Market 2026
300K+
CircleDNA Tests Processed
Speaker
We sit at the intersection of three massive markets: consumer genomics, nutrigenomics, and longevity. APAC DTC genetics alone is growing to $1.5 billion by 2030. Our Year 1 SOM is $27K ARR — conservative and bottom-up.

Business Model

Free Insight, Paid Protocol

Free Tier
Capture & Convert
Upload DNA report
Basic genetic summary
Top risk highlights
Data capture for conversion
Premium
$25/monthor $249/year (save 17%)
Personalized supplement stacks
Nutrition & exercise protocols
Blood panel cross-analysis
Living updates & protocol evolution

Family Plans: $39/mo  |  Practitioner SaaS: $99–$299/mo (Phase 2)  |  Annual plans reduce churn by 51%

65–70%
Gross Margin
5:1
LTV:CAC
$40
Blended CAC
$25/mo
ARPU
Speaker
Free tier captures data and demonstrates value. Premium anchored at $25 per month — less than half what SelfDecode charges annually, but with living protocols, Chinese AI, and multi-source integration. Annual plans reduce churn by 51%. Unit economics: $40 CAC, $250 LTV, 5:1 ratio.

Go-to-Market

Capture High-Intent Users at the Moment of Curiosity

CircleDNA Aftermarket

Highest conversion

Target users who spent $400–$600 on a DNA test and are searching “what do my results mean?”

Longevity Communities

Community-led

Bryan Johnson’s Don’t Die community (13K+ Discord). Biohacking communities in HK and SG.

Practitioner Network

B2B referral

Free practitioner accounts for functional medicine doctors. Trusted recommendation channel with high conversion.

Content-Led Growth

SEO + social

Definitive content library for DNA report interpretation in English and Chinese. Captures organic traffic at peak curiosity.

Speaker
Highest-conversion channel: CircleDNA users who already spent $400-600 and are searching for what to do next. Zero paid acquisition needed.

Financial Projections

Conservative 3-Year Forecast

Annual Recurring Revenue
$27K
Year 1
HK
$108K
Year 2
HK+SG+TW
$360K
Year 3
+UK, AU/NZ
Bottom-up: 3% freemium conversion, $25/mo ARPU, 8% monthly churn
Use of Micro Fund
50% Product R&D
20% Cloud & API costs
15% Beta user acquisition
15% Market validation
Unit Economics
$40
Blended CAC
$250
Lifetime Value
5:1
LTV:CAC Ratio
65–70%
Gross Margin
Y1
Y2
Y3
Free users
3,000
12,000
40,000
Paid subs
90
360
1,200
MRR (end)
$2.3K
$9K
$30K
ARR (end)
$27K
$108K
$360K
Milestone
PMF
Expansion
Pre-Series A
Speaker
Conservative bottom-up projections grounded in industry benchmarks. 3% freemium conversion (industry average 2–5%), $25 ARPU, 8% monthly churn. Projected LTV:CAC of 5:1, comfortably above the 3:1 benchmark (a16z). We reach $360K ARR by Year 3 across 5 markets.

Regulatory Positioning

Wellness Platform, Not Medical Device

Clear regulatory path with a proven industry playbook — the same model SelfDecode, Promethease & GenomeLink operate under.

Our Classification

Wellness, not diagnostic — we interpret, we don’t diagnose or treat
No disease claims or treatment recommendations
FDA General Wellness exemption — not a regulated medical device
“Consult your healthcare provider” guidance throughout product

Data Privacy

PDPO-compliant (Hong Kong) — explicit consent, secure handling, user deletion rights
GDPR-ready architecture for UK/EU expansion (Phase 3)
PDPA-aware (Singapore) for Phase 2 readiness
Genetic data encrypted at rest and in transit

Risk Mitigation

Comprehensive Terms of Service with medical disclaimers
Algorithm transparency — no black-box claims, sources cited
Competitor-validated model — SelfDecode, Promethease, GenomeLink all operate successfully under this framework
Regular legal & compliance reviews per jurisdiction
HK has no DTC genetics-specific regulation — one of the lightest regulatory environments for our beachhead. APAC-wide, genetic discrimination law is minimal, reducing litigation risk.
Speaker
We’re not the first to do this. SelfDecode, Promethease, and GenomeLink all use the same wellness positioning successfully. The regulatory playbook is proven. And Hong Kong is one of the lightest regulatory environments for health tech, which is why it’s our beachhead.

Traction & Validation

Built, Not Just Planned

Working Prototype

Live
PDF parsing pipeline for CircleDNA
AI/RAG engine with hallucination guards
Frontend dashboard UI
End-to-end upload → protocol flow

Validated Problem

Confirmed
Real CircleDNA WES reports tested
Family DNA + blood panel cross-analysis
Confirmed the “so what?” gap firsthand
Production-ready architecture defined

Advisory Network

Active
Domain advisors engaged
Business Master Plan completed
14-week Phase 1 sprint plan ready
GCP-integrated tech stack finalized
Speaker
Working prototype, validated problem with real DNA reports, and advisory network in place. This isn't a concept — it's code.

The Team

Built by Builders Who’ve Shipped Together

Billy Lui
Billy Lui
Co-Founder
CUHK

10 years leading venture-backed software startups. Product design & management expert across enterprise, blockchain, and AI.

Ex-HK Team Swimmer HKSI Elite Athlete Biohacker
Andy Lam
Andy Lam
Co-Founder
PolyU

18 years in systems engineering. Built front-office trading systems, portfolio analytics, and big data platforms. Plug and Play alum.

MSc Applied Math BA Computing Adtech & Data Infra
Eric Cheung
Eric Cheung
Co-Founder
PolyU · CityU

17 years full-stack systems engineering. AWS data pipelines, Kubernetes, Spark ML, blockchain.

BSc Applied Physics 2× MSc (Math + CS) 17 Years Engineering
8+ years building venture-backed startups together. Proven co-founders with venture-backed startup experience.
Speaker
Three co-founders with 8+ years building venture-backed startups together. Andy is a Plug and Play alum. Billy is a former Hong Kong team swimmer turned biohacker — this problem is personal.

The Ask

PolyU Micro Fund — Fuel for Product-Market Fit

What We Deliver in 6 Months
MVP: CircleDNA PDF → personalised protocol pipeline
100–200 beta users in Hong Kong validating PMF
Lean Launchpad milestones (Jun–Jul 2026)
Foundation for Chinese-language expansion
Fund Allocation
50%Product R&D (MVP → beta)
20%Cloud infrastructure & API costs
15%Beta user acquisition (100–200 in HK)
15%Market validation & research
Next round: Angel/Pre-seed after PMF validation in HK

The next great health platform won’t generate more data.
It will make existing data actionable.

150 Club  |  Your Longevity Starts Here.

Speaker
We’re asking for PolyU Micro Fund support to reach product-market fit in Hong Kong. 50% goes to product R&D, 20% to cloud infrastructure, 15% to acquiring 100–200 beta users, 15% to market research. Once we validate PMF, the next step is an angel or pre-seed round to expand into Singapore and Taiwan.

Appendix — Core Technology

4-Layer Health Intelligence Architecture

Genetic Layer
Static
Your DNA blueprint — SNPs, pharmacogenomics (93.5% carry actionable variants — PREPARE trial, Lancet 2023), polygenic risk scores. Immutable data, continuously re-interpreted.
Biomarker Layer
Periodic
Blood panels, metabolic markers, hormones. Validates whether genetic risks have materialized.
Lifestyle Layer
Continuous
Wearable data — HRV, sleep, activity, nutrition. Measures protocol adherence in real time.
Environmental Layer
Contextual
Air quality, UV index, pollen, location. Adapts protocols to real-world conditions.

The LLM never invents health claims. It only interprets what these four verified data layers have established.

Speaker
APPENDIX: Four verified data layers ground every AI output. The LLM never invents — it only interprets.

Appendix — Defensibility

5-Layer Competitive Moat

1

Multi-Source Ingestion

Accept reports from any DNA provider. We are the aggregation layer.

2

4-Layer Ground Truth

Deterministic data model compounds with every data point a user adds.

3

Chinese-Language AI

First-to-market with native Chinese genetic interpretation + TCM integration.

4

Ancestry-Calibrated

Algorithms tuned for East Asian populations using ChinaMAP & regional biobanks.

5

Family Network Effects

Each family member added multiplies engagement and raises switching costs.

No Western competitor can credibly replicate Chinese-language AI interpretation + TCM-genomics integration for 1.5B Chinese speakers.
Speaker
APPENDIX: Five layers of defensibility. The critical one: we’re first to market with Chinese-language AI genetic interpretation.

Appendix — Why Now

Three Forces Converging

23andMe Trust Crisis

Filed Chapter 11, acquired in a $305M fire sale. 1.9 million users demanded data deletion. 28 attorneys general sued. Trust in legacy genetic testing is shattered.

Trust Vacuum

Longevity Goes Mainstream

Investment in longevity surged 2.2× to $8.5B in 2024. Bryan Johnson’s Blueprint raised $60M. Biohacking market at $24.8B growing 19% CAGR.

Consumer Demand

LLMs Unlock Interpretation

For the first time, AI can interpret genetic variants against research databases in real time — at a fraction of the cost of a geneticist or functional medicine doctor.

Tech Enabler
The window is open now. Legacy players are failing, consumers are ready, and AI finally makes genetic interpretation scalable.
Speaker
APPENDIX: Three forces converging — 23andMe trust crisis (1.9M deletions, 28 AGs sued), longevity investment surged 2.2× to $8.5B, and LLMs unlock real-time genetic interpretation.

Appendix — Solution Detail

From Dead PDF to Living Protocol

150 Club transforms static DNA reports into personalized, evolving health protocols — powered by AI, grounded in verified science.

Before
84-page PDF report filed away
Generic risk percentages
No connection to blood work
Never updates with new research
English only for APAC users
CircleDNA Report
84 pages · PDF
Diabetes Risk: 23% Heart: Moderate 574 variants
No actionable steps provided
After — 150 Club
Personalized supplement stacks
Nutrition & exercise protocols
DNA + blood panel cross-analysis
Living updates as science evolves
Full Chinese-language support
Your Dashboard
80
Health
Today’s Protocol
Vitamin D34,000 IU
Omega-32g/day
Methylfolate800mcg
✓ Updated 2 days ago with new research
Speaker
APPENDIX: We turn this dead PDF into a living, personalized health protocol. Supplements, nutrition, exercise — all tailored to your DNA.

Appendix — Product Flow

From Upload to Protocol in Minutes

01

Upload

Drop your CircleDNA PDF. Our parser extracts every variant automatically.

< 2 min
Upload Report
CircleDNA_WES_Report.pdf
7.3 MB
Analyze My DNA
02

Analyze

AI cross-references variants against ClinVar, PharmGKB & our knowledge base.

< 3 min
Risk Overview
574 traits
Low 389
Moderate 142
High 43
80 Diet
60 Fitness
90 Wellness
03

Protocol

Personalized supplements, nutrition & exercise — grounded in evidence.

< 10 min
Your Protocol
Essential Vitamin D3 4,000 IU/day
Essential Omega-3 (EPA/DHA) 2g/day
Recommend Methylfolate (5-MTHF) 800mcg/day
Mediterranean Diet Pattern
Power/HIIT Training Focus
Speaker
APPENDIX: Three steps. Upload, analyze, protocol. Ten minutes total from raw DNA data to personalized health plan.

Appendix — Expansion Roadmap

Follow CircleDNA’s Footprint

Our MVP parses CircleDNA reports. Wherever they’ve sold tests, there’s an aftermarket of users who need our product. CircleDNA ships to 80+ countries.

Phase 1 · Mo 1–12

Hong Kong

CircleDNA HQ, bilingual market, no DTC regulation, team based here.

3K free · 90 paid
Phase 2 · Mo 12–24

Singapore + Taiwan

CircleDNA sells via Watsons (TW). Prenetics office in SG, affluent biohacking market.

12K free · 360 paid
Phase 3 · Mo 24–36

UK + AU/NZ

CircleDNA London office. English-speaking premium health markets. Add B2B practitioner channel.

40K free · 1.2K paid
Phase 4 · Mo 36+

US + Global

Largest consumer health market. Post-23andMe trust crisis: millions seeking alternatives. Requires Series A.

Crossing the Chasm
Each phase follows CircleDNA’s existing customer base. We don’t need to educate the market — they already have the data.
Speaker
APPENDIX: We follow CircleDNA’s footprint. They ship to 80+ countries. Wherever they’ve sold a test, there’s a user who needs our product. Phase 1 is Hong Kong where they’re headquartered.
150 Club