150 Club

Make precision health the default.

Substrate-aware protocol engine — Start in Asia. Built for the world.

Techstars Confidential
Speaker
We are 150 Club. We turn your genome and biomarkers into an evolving protocol — what to do today, refreshed by every blood draw and wearable signal. Make precision health the default.

The Problem

The “So What?” Gap

The painkiller problem
“The slide toward diabetes and heart disease is silent — reversible if caught early, but the system stays reactive until you’re already sick.”
Reactive, Not Preventive
Care waits until you’re sick. The reversible window is missed.
Drowning in Data, No Plan
DNA, labs, wearables — separate worlds, no protocol.
Generic Advice, Nothing Accumulates
Even AI answers from population averages — wrong for you.

The Opportunity

~12%
of adults are metabolically healthy
Araújo et al., NHANES 2009–16
~74%
of global deaths from chronic disease — largely preventable
WHO / Lancet
68%
variation in glucose response to the same meal — generic advice is wrong for you
PREDICT I, Cell 2015 / Nat Med 2020

“Chronic disease is largely preventable — yet only ~12% of adults are metabolically healthy. The slide is silent and reversible, but care stays reactive, and nothing you learn accumulates.”

Speaker
Chronic disease is largely preventable, yet only about 12% of adults are metabolically healthy. The slide toward diabetes and heart disease is silent and reversible if caught early — but the system stays reactive until you’re sick. The motivated drown in DNA, lab, and wearable data with no plan. And even AI answers from population averages, while individual responses to the same meal vary up to 68% — so generic advice is wrong for you, and nothing accumulates over time.

The Solution

An Evolving Protocol, Not a Dead Report

01

Upload

Drop your DNA report. Auto-extract every variant.

< 2 min
Upload Report
CircleDNA_Report.pdf
7.3 MB
Analyze My DNA
02

Analyze

Self-improving health intelligence cross-references ClinVar & PharmGKB.

< 3 min
Risk Overview
574 traits
Low 389
Mod 142
High 43
03

Protocol

What to take, when, why — every recommendation cited.

< 10 min
Your Protocol
Essential Vitamin D3 4K IU
Essential Omega-3 2g
Recommend Methylfolate 800mcg
Mediterranean Diet
04

Track & Evolve

Blood draws + wearables redesign your protocol on live data.

Ongoing
Biomarker Trends
Vitamin D (ng/mL)
JanMarJunSep
45
ng/mL
Updated D3: 4K→2K IU

We don’t ship a score — we ship what to do tomorrow. Lifestyle, nutrition & supplements today; the routing layer for precision therapy tomorrow.

Speaker
We turn your genome and biomarkers into an evolving protocol, powered by self-improving health intelligence: what to take, when, and why — every recommendation cited. It’s refreshed by every blood draw and wearable signal. We don’t ship a score, we ship what to do tomorrow. Lifestyle, nutrition, and supplements today; routing to precision therapy tomorrow.

The Vision

Your DNA Is Just the Start

Genetic data alone drives ~0% behavior change (Hollands, BMJ 2016). 150 Club closes the loop on ground truth — a compounding personal health context that sharpens the longer you stay.

Genetic
Foundation
Insights
DNA + lab results decoded into plain-language findings
Protocols
Personalized supplements, nutrition & exercise plans
Action
Guided daily routines integrated into real life
Outcomes
Measurable biomarker improvements & health changes
AI generates plans
Guided routines
Health changes
New data refines AI
1

Compounding Health Context

Every cycle adds ground truth. The protocol learns what works for YOUR genetics & biomarkers.

2

Living, Not Static

Protocols evolve with new research, new blood work, and new outcomes. Never a dead PDF again.

3

Defensible Moat

Our moat isn’t the DNA report — it’s the continuous redesign of protocols on ground truth no platform can scrape.

Every turn of the flywheel makes the AI smarter and protocols more precise. Static reports can’t do this.
Speaker
Genetic data alone has zero percent effectiveness at driving behavior change. But when you close the loop — biomarker feedback, an evolving protocol, guided action, and outcome tracking — every cycle adds ground truth and the system sharpens. Our moat isn’t the DNA report; it’s the compounding personal health context.

Competitive Landscape

Where We Sit

Genome Depth →
Closed Loop on Ground Truth →
Nucleus
SelfDecode
WHOOP / Oura
Function / Superpower
150 Club
Genome + Living Protocol
A Number, Not a Protocol
AI Genomics
Score Trackers
Two Kinds of Players
Score-Output Trackers — WHOOP, Oura, Function, Superpower, Tally
They give you a number, not a protocol. No genome, no plan for tomorrow morning.
Direct AI Genomics — Nucleus Genomics, SelfDecode
Nucleus: single-genome, US-only, AI doctor. SelfDecode: English-only, European data. A one-time read, not a closed loop.
DNA providers are complementary substrate
Their reports are inputs to our loop, not competition. We’re report-format-agnostic by design.
Nucleus
Self
Decode
WHOOP
150
Club
Genome depth
Evolving protocol (not a score)
One-time
One-time
Score
Closed loop on ground truth
Tracking
Any DNA provider
N/A
Owned APAC clinic ops

Only 150 Club redesigns protocols on live ground truth and owns the APAC clinical operation — not a one-time genome read, not a number.

Speaker
Two kinds of players. Score-output trackers — WHOOP, Oura, Function, Superpower, Tally — give you a number, not a protocol. The direct ones are AI genomics platforms: Nucleus Genomics is single-genome, US-only, with an AI doctor; SelfDecode is English-only on European data. We differ on the loop — we redesign protocols on live ground truth and own the APAC clinical operation, not a one-time genome read. DNA providers are complementary substrate; their reports are inputs to our loop.

Market Opportunity

The Size of the Prize

2034 Precision-health market — large, unowned, contested $511B
2025 Precision-health market today — 15.4% CAGR $141B
Wedge APAC beachhead — HK → APAC cities → SEA → global APAC
Category Substrate-aware protocol engine Make precision health the default
$141B
Precision-health market, 2025
$511B
Projected by 2034
15.4%
CAGR, 2025–2034
Unowned
No venture-backed consumer brand owns the category
Speaker
The precision-health market is large and unowned — $141 billion now, growing to $511 billion by 2034. No venture-backed consumer brand has won the category. We define it: make precision health the default, starting from an APAC beachhead and built for the world.

Business Model

Free Insight, Paid Evolving Protocol

Free
$0
Upload your DNA — one-time protocol
Data integration (wearables + labs)
Tracking tools
Core
$249/year
Evolving protocol from self-improving health intelligence
Includes a free DNA test
Refreshed on your live data
Longevity
$999/year
Annual methylation + 2 blood panels
Clinician review
WGS upgrade

Concierge — custom-quoted to goals and tests. Recurring, software-driven, scalable.

$249
Core ARPU / year
$999
Longevity ARPU / year
Recurring
Annual memberships
Software
Driven & scalable
Speaker
Memberships by tier. Free: upload your DNA for a one-time protocol with data integration and tracking tools. Core, $249 a year: an evolving protocol from self-improving health intelligence, plus a free DNA test. Longevity, $999 a year: adds annual methylation, two blood panels, a clinician review, and a WGS upgrade. Concierge is custom-quoted. Recurring, software-driven, and scalable.

Go-to-Market

A Year-One No-Brainer, Then Channels That Compound

Consumer No-Brainer

Year-one wedge

Annual Core membership includes a free DNA test — the bundle still costs less than half of CircleDNA’s premium test alone. DNA-curious buyers become members from day one.

APAC Clinic Partnerships

Second channel

Partner clinics recommend 150 Club to patients already investing in their health — and run the blood draws that feed the loop.

City Expansion

APAC → SEA

HK beachhead, then Singapore, Taipei, Greater Bay Area, and SEA — replicating the clinic-partnership model city by city.

Insurer Bundling

Distribution at scale

Bundle preventive protocols into insurer offerings — value-based by design, distribution at population scale.

Speaker
At the consumer level, year one is a no-brainer: an annual Core membership includes a free DNA test, and the bundle still costs less than half of CircleDNA’s premium test alone. That turns people curious about their DNA into members from day one. APAC clinic partnerships are a second channel, recommending 150 Club to patients already investing in health. Then city expansion and insurer bundling.

Financial Projections

Conservative 3-Year Forecast

Annual Recurring Revenue
$350K
Year 1
HK
$1.8M
Year 2
HK+SG+TW
$6.5M
Year 3
+SEA
Bottom-up: annual memberships — Core $249/yr, Longevity $999/yr, blended ARPU ~$350; ~10% free→paid conversion
Revenue Drivers
Core $249/yr + free DNA test
Longevity $999/yr labs + review
Concierge custom-quoted
Recurring software-driven
Unit Economics
~$140
Blended CAC
~$700
Lifetime Value
5:1
LTV:CAC Ratio
>70%
Gross Margin
Y1
Y2
Y3
Free users
10,000
50,000
180,000
Paid members
1,000
5,000
18,000
Blended ARPU
$350
$360
$360
ARR (end)
$350K
$1.8M
$6.5M
Milestone
PMF
Expansion
Pre-Series A
Speaker
Conservative bottom-up projections on annual memberships. Core at $249 a year with a free DNA test; Longevity at $999. Roughly $6.5M ARR by Year 3 across APAC, on about 18,000 paid members at a blended $350 ARPU, with 5:1 LTV:CAC and software-level gross margins. The free DNA test sits in CAC and is funded by the annual prepay.

Regulatory Positioning

A Software Platform, Not a Medical Device

A precision-health software platform — we route the medical loop to licensed (PHFO) partner clinics. We do not diagnose, treat, or cure.

Our Classification

Software platform, not a medical device — precision-health, not diagnostic
No disease claims; we do not diagnose, treat, or cure
Medical loop routed to licensed (PHFO) partner clinics
“Consult your healthcare provider” guidance throughout product

Data Privacy

PDPO-compliant (Hong Kong) — explicit consent, secure handling, user deletion rights
GDPR-ready architecture for UK/EU expansion (Phase 3)
PDPA-aware (Singapore) for Phase 2 readiness
Genetic data encrypted at rest and in transit

Risk Mitigation

Comprehensive Terms of Service with medical disclaimers
Algorithm transparency — no black-box claims, sources cited
Competitor-validated model — SelfDecode, Promethease, GenomeLink all operate successfully under this framework
Regular legal & compliance reviews per jurisdiction
HK has no DTC genetics-specific regulation — one of the lightest regulatory environments for our beachhead. APAC-wide, genetic discrimination law is minimal, reducing litigation risk.
Speaker
We’re not the first to do this. SelfDecode, Promethease, and GenomeLink all use the same wellness positioning successfully. The regulatory playbook is proven. And Hong Kong is one of the lightest regulatory environments for health tech, which is why it’s our beachhead.

Traction & Validation

Built, Not Just Planned

Platform Live

Live
DNA ingestion + annotation pipeline
Cited protocol engine with hallucination guards
Wearable + blood-panel integration
End-to-end upload → evolving protocol

Live Private Beta

Active now
5 handpicked members active, DNA uploaded
~10 protocol renewals/week across the cohort
Driven by live wearables + periodic blood panels
The loop works.

What’s Next

Goal
Prove continuous updates sustain engagement
Convert beta to paid
Grow to 50 engaged members
Deepen the loop with richer inputs
Speaker
The platform is live. Five handpicked private beta members are active right now, DNA uploaded, averaging about ten protocol renewals a week from live wearables and periodic blood panels. The loop works. Our goal is to prove continuous updates sustain engagement, convert to paid, and grow to fifty.

The Team

Lived Founder-Market Fit, Proven Ability to Scale

Billy Lui
Billy Lui
Co-Founder
CUHK

National-level swimmer (HK national squad) turned founder. 9 years building products. Built the platform and is its first user — running his own protocols off his genome.

HK National Swimmer 9 Yrs Building Products Product’s First User
Andy Lam
Andy Lam
Co-Founder
PolyU

Built AlikeAudience — a data platform processing billions of profiles across 14 markets — through a Silicon Valley accelerator. Deep VC network across the US and Asia.

Billions of Profiles · 14 Markets SV Accelerator Alum US + Asia VC Network
Lived founder-market fit, paired with a proven ability to scale. Two co-founders covering the build and the operation underneath it.
Speaker
Two co-founders. Billy is a national-level swimmer turned founder — he built the platform and runs his own protocols off his genome, the product’s first user. Andy built AlikeAudience to billions of profiles across 14 markets through a Silicon Valley accelerator, with a deep VC network across the US and Asia. Lived founder-market fit, paired with a proven ability to scale.

The Ask

Techstars — operators and network to own the APAC clinical loop

Our Next Milestones
Sign first APAC clinic partnerships — blood-panel testing + data integration
Own blood-draw scheduling, location & supply chain — feeding the loop
Convert the active beta to paid
Grow to 50 engaged members
Deepen the loop with richer wearable & blood inputs
Where Techstars Helps
Operatorswho have scaled clinical and consumer health
Networkto build the clinic-partnership model the right way
Capital & rigorto prove the loop sustains engagement and willingness to pay
Key question: do continuously updated protocols sustain engagement and willingness to pay?

We don’t ship a score. We ship what to do tomorrow.
Make precision health the default.

150 Club  |  Make precision health the default.

Speaker
Our next step is to sign our first APAC clinic partnerships for blood-panel testing and data integration — owning the blood-draw scheduling, location, and supply chain that feed the loop. In parallel, convert the active beta to paid and grow to fifty engaged members. We’re applying to Techstars for the operators and network to build the clinical loop the right way. Make precision health the default.

Appendix — Core Technology

4-Layer Health Intelligence Architecture

Genetic Layer
Static
Your DNA blueprint — SNPs, pharmacogenomics (93.5% carry actionable variants — PREPARE trial, Lancet 2023), polygenic risk scores. Immutable data, continuously re-interpreted.
Biomarker Layer
Periodic
Blood panels, metabolic markers, hormones. Validates whether genetic risks have materialized.
Lifestyle Layer
Continuous
Wearable data — HRV, sleep, activity, nutrition. Measures protocol adherence in real time.
Environmental Layer
Contextual
Air quality, UV index, pollen, location. Adapts protocols to real-world conditions.

The LLM never invents health claims. It only interprets what these four verified data layers have established.

Speaker
APPENDIX: Four verified data layers ground every AI output. The LLM never invents — it only interprets.

Appendix — Defensibility

5-Layer Competitive Moat

1

Compounding Health Context

The closed loop on ground truth — each blood draw and wearable signal redesigns the protocol, so it sharpens the longer you stay.

2

Owned APAC Clinic Operations

We run members’ blood draws — scheduling, location, data integration. Software-only rivals can’t copy the operation.

3

Clinical & Regulatory Trust

The barrier is trust earned with clinics and regulators — not a feature a competitor can ship overnight.

4

Un-Scrapeable Biological Data

Longitudinal genome × biomarker × outcome data no platform can scrape from the web.

5

Report-Format-Agnostic

Any DNA provider is complementary substrate. The moat is the redesign loop, not report coverage.

Software-only rivals can’t copy the owned clinical operation or the un-scrapeable biology. The barrier is clinical trust plus a compounding closed loop on ground truth.
Speaker
APPENDIX: The moat is two things — a compounding personal health context (the closed loop on ground truth) and an owned APAC clinic operation that runs the blood draws and feeds the loop. The barrier is clinical and regulatory trust, plus biological data no platform can scrape.

Appendix — Why Now

Three Forces Converging

AI Reasoning Is Finally Good Enough

For the first time, AI can turn a genome plus biomarkers into a continuously redesigned protocol. What once needed a concierge team at great cost — or was impossible — one person can now run.

A context can compound

Precision Health: Clinic → Home

Precision health is moving from the clinic into the home. Apple Health and Health Connect made personal health data ubiquitous — the inputs to the loop are already in everyone’s pocket.

Data is ubiquitous

Genome Costs Collapsed

As DNA costs trend toward zero and intelligence becomes abundant, designing and running a protocol for one person becomes possible at scale — not just for a wealthy few.

Cost enabler
This is the first time a personal health context can compound — genome costs collapsed, data is ubiquitous, and AI can finally redesign a protocol continuously.
Speaker
APPENDIX: Three forces converging — AI reasoning is finally good enough to turn a genome plus biomarkers into a continuously redesigned protocol, precision health is moving from clinic to home with Apple Health and Health Connect making data ubiquitous, and genome costs have collapsed. For the first time, a personal health context can compound.

Appendix — Solution Detail

From Dead Report to Evolving Protocol

150 Club turns a static DNA report into an evolving protocol — powered by self-improving health intelligence, every recommendation cited, refreshed on your live data.

Before
84-page PDF report filed away
Generic risk percentages
No connection to blood work
Never updates with new research
English only for APAC users
CircleDNA Report
84 pages · PDF
Diabetes Risk: 23% Heart: Moderate 574 variants
No actionable steps provided
After — 150 Club
Personalized supplement stacks
Nutrition & exercise protocols
DNA + blood panel cross-analysis
Living updates as science evolves
Full Chinese-language support
Your Dashboard
80
Health
Today’s Protocol
Vitamin D34,000 IU
Omega-32g/day
Methylfolate800mcg
✓ Updated 2 days ago with new research
Speaker
APPENDIX: We turn a dead report into an evolving protocol — supplements, nutrition, and lifestyle tailored to your genome and refreshed on your live data, every recommendation cited.

Appendix — Product Flow

From Upload to Protocol in Minutes

01

Upload

Drop your CircleDNA PDF. Our parser extracts every variant automatically.

< 2 min
Upload Report
CircleDNA_WES_Report.pdf
7.3 MB
Analyze My DNA
02

Analyze

AI cross-references variants against ClinVar, PharmGKB & our knowledge base.

< 3 min
Risk Overview
574 traits
Low 389
Moderate 142
High 43
80 Diet
60 Fitness
90 Wellness
03

Protocol

Personalized supplements, nutrition & exercise — grounded in evidence.

< 10 min
Your Protocol
Essential Vitamin D3 4,000 IU/day
Essential Omega-3 (EPA/DHA) 2g/day
Recommend Methylfolate (5-MTHF) 800mcg/day
Mediterranean Diet Pattern
Power/HIIT Training Focus
Speaker
APPENDIX: Three steps. Upload, analyze, protocol. Ten minutes total from raw DNA data to personalized health plan.

Appendix — Expansion Roadmap

Follow CircleDNA’s Footprint

CircleDNA is complementary substrate, not competition — their reports are inputs to our loop. Wherever they’ve sold tests, there’s an installed base who need an evolving protocol. CircleDNA ships to 80+ countries.

Phase 1 · Mo 1–12

Hong Kong

CircleDNA HQ, bilingual market, no DTC regulation, team based here.

3K free · 90 paid
Phase 2 · Mo 12–24

Singapore + Taiwan

CircleDNA sells via Watsons (TW). Prenetics office in SG, affluent biohacking market.

12K free · 360 paid
Phase 3 · Mo 24–36

SEA

Bangkok, Jakarta, KL, Manila. Regional clinic partners + insurer bundling. Replicate the loop city by city.

40K free · 1.2K paid
Phase 4 · Mo 36+

Global

Selected Tier 1 cities outside Asia — US, UK, EU — as the clinical-partner federation matures. Requires Series A.

Built for the world
Each phase follows an existing installed base of DNA-tested users — complementary substrate, not competition. We don’t need to educate the market; they already have the data.
Speaker
APPENDIX: We follow CircleDNA’s footprint. They ship to 80+ countries. Wherever they’ve sold a test, there’s a user who needs our product. Phase 1 is Hong Kong where they’re headquartered.
150 Club